Blocking TGFβ-receptor signaling with SB-431541 significantly reduced mRNA-expression of ER-stress markers DDIT3 (Figure 4—figure supplement 1C), spliced XBP1 (Figure 4—figure supplement 1D) and HSPA5 (Figure 4—figure supplement 1F) in stellate cells co-cultured with tumor cells using transwells. The gene discussed is HSPA5; the disease is neoplasm.