Results showed that the expression levels of pro-apoptotic factor (Bax), Cleaved caspase-3 and Cleaved caspase-9 were all significantly up-regulated while the expression of anti-apoptotic factor (Bcl-2) was significantly down-regulated in NSCLC cells when treated by miR-371b-5p inhibitor. The gene discussed is BCL2; the disease is non-small cell lung carcinoma.