AGT and endothelial dysfunction: Direct viral invasion of endothelial cells causes an inflammation or “endothelitis” which has been proposed as one of the substrates for the thrombotic complications of COVID-19.44 Moreover, binding of SARS-CoV-2 to ACE-2 receptor causes a depletion of its availability through endocytosis and ultimately a downregulation of the renin angiotensin system (RAS).45 In fact, the unopposed generation of Angiotensin II, no more counterbalanced by Angiotensin 1-7, worsens lung injury and is also responsible for endothelial dysfunction in organs like the heart and brain.