While microbiota depletion in mice has been shown to be harmful during myocardial infarction (MI),14 it protects from autoimmune myocarditis15 and was reported to be beneficial in angiotensin-II induced hypertension.16 This somewhat parallels observations in T cell-deficient mice demonstrating that while T cells are required for myocardial healing after MI,17 they are detrimental in inflammation associated with hypertension.18 These results suggest the intriguing possibility that microbiota may go along with T cell activation in cardiac inflammation. Here, AGT is linked to hypertensive disorder.