The potential roles of GAS2 protein in tumorigenesis of liver cancer,13, 35 leukaemia,36, 48, 51, 52, 53, 54 recurrent colorectal cancer,55, 56, 57 prostate cancer,58 breast cancer 44, 59 or lung adenocarcinoma 60 have been explored, but there are very few studies related to GAS2L1, GAS2L2 and GAS2L3. This evidence concerns the gene GAS2 and Familial prostate cancer.