NFE2L2 and type 2 diabetes mellitus: This notion is further supported by results from a human study showing that a 12-week intervention with the classical Nrf2 activator SFN (administered as broccoli sprout extracts) improved glucose control in obese patients with type 2 diabetes, as evidenced by the decrease in glycated hemoglobin and fasting blood glucose, which correlated with serum SFN concentration (Axelsson et al., 2017).