Thus, Ces1 deficiency results in hepatosteatosis (Quiroga et al., 2012), and albeit to a much lower degree, there is evidence for microvesicular hepatic steatosis in Nrf2-KO animals (Chowdhry et al., 2010; Meakin et al., 2014; Sugimoto et al., 2010). This evidence concerns the gene CES1 and fatty liver disease.