As in mouse cells and tissues, treatment with TBE-31 or the naturally occurring Nrf2 activator sulforaphane (SFN) upregulated the expression of CES1 in the human hepatoma cell line HepG2, which has high basal levels of CES1 (Figure S6A), in a manner resembling that of NQO1 (Figure S6B) and GCLC (Figure S6C). The gene discussed is GCLC; the disease is hepatocellular carcinoma.