CASR and hypoparathyroidism: Moreover, these findings differentiate ADH1 from hypoparathyroidism, which is generally associated with irreversible destruction of the parathyroid glands.(34) Bolus dose administration of NPSP795 also significantly increased plasma calcium concentrations in Casr+/Nuf and CasrNuf/Nuf mice, and the 0.2 to 0.3 mmol/L increase in plasma calcium was similar to that observed in WT mice treated with NPSP795 (Fig. 3).