After 4 weeks of HFD‐feed, the plasma insulin value was higher from 1.72 ± 0.058 to 2.61 ± 0.088 mIU/L (p < 0.001) in the control to the T2D groups, respectively, which evidenced the condition of hyperinsulinemia caused by insulin resistance. The gene discussed is INS; the disease is Insulin resistance.