There are many treatments options for peptic ulcer like (proton pump inhibitors, histamine-2 receptor blockers, prostaglandin analogue, misoprostol, bismuth sucralfate, and antibiotics for eradication of H. pylori, But treatment of peptic ulcer becomes difficult with these drugs because of unpredictable adverse effects of these drugs when used for a long term (Cadirci et al., 2007). Here, ATP12A is linked to peptic ulcer disease.