A model that combines CK18 fragments with C‐terminal cleavage site of procollagen type III N‐terminal peptide (Pro‐C3), acetyl‐high mobility group box 1 and patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) rs738409 had the highest reported accuracy to diagnose NASH with an AUROC of 0.87, Sn 71% and Sp 87%, though these results have not been externally validated.37 Here, PNPLA3 is linked to metabolic dysfunction-associated steatohepatitis.