Elevated FGF2 has been observed in patients with advanced liver fibrosis21 and has been reported to be involved in the development and progression of HCC.21, 22, 23 In addition to other FGFs, FGF19 and 21 function as endocrine hormones22; therefore, they may be suitable serum biomarker candidates. The gene discussed is FGF2; the disease is hepatocellular carcinoma.