ANGPT2 and hepatocellular carcinoma: Elevated serum ANG‐2 levels are sometimes observed in patients with HCC.20 Increased ANG2 confers poor prognosis in patients with unresectable HCC12; however, its role as a predictive biomarker for sorafenib therapy remains controversial.11 In addition, the impact of increased ANG2 levels on treatment response to lenvatinib has not been elucidated.