M2BPGi, which is mainly produced by hepatic stellate cells and may interact with Mac‐2 positive cells such as macrophages to induce biological activity, is a reliable marker for assessing liver fibrosis in patients with viral hepatitis and other fibrotic liver diseases, such as primary biliary cholangitis, biliary atresia, autoimmune hepatitis, and NAFLD.14, 15. Here, LGALS3 is linked to primary biliary cholangitis.