To evaluate which markers are effective for identifying HCC patients in the clinic, we assessed common fibrosis markers, such as M2BPGi, ATX, FIB‐4 index, and platelet count (without distinguishing them based on the etiology [HBV, HCV, NASH, and ASH]), in patients with or without HCC. Here, ENPP2 is linked to hepatocellular carcinoma.