In HCV patients, a small‐sized HCC was detected in patients with 1 > M2BPGi > 0.5 or 1 > ATX > 0.5 (9 mm, 12 mm, and 32 mm for M2BPGi and 20 mm, 32 mm, 20 mm, and 14 mm for ATX) during regular follow‐up. Here, ENPP2 is linked to hepatocellular carcinoma.