In this study, we first focused on serum markers that had recently become available, namely, Wisteria floribunda agglutinin+—Mac‐2 binding protein (WFA+‐M2BP; M2BPGi),14, 15 autotaxin (ATX),16 platelet count,17 and the fibrosis‐4 (FIB‐4) index,18 to generate data that took into consideration HCC patients in the clinic. The gene discussed is ENPP2; the disease is hepatocellular carcinoma.