OBI can manifest in four forms of clinical conditions: recovery from past infection indicated by the presence of hepatitis B surface antibodies (anti‐HBs); chronic hepatitis with surface gene escape mutants that are not recognized by current assays; chronic carriage without any marker of HBV infection other than HBV‐DNA (referred to as “seronegative”); and chronic carriage stage with HBsAg too low to be detected and recognized by the presence of anti‐HBc as the only serological marker (referred to as “anti‐HBc alone” or “isolated anti‐HBc”).9 Here, KRT88P is linked to chronic hepatitis.