KEGG pathways’ investigation confirmed the pathways associated with the role of mutations in TRIP-Brs and other mutated neighbor genes; thyroid hormone signaling pathway, ErbB signaling pathway, small cell lung cancer, hepatitis B, endometrial cancer, PI3K-Akt signaling pathway, chronic myeloid leukemia, central carbon metabolism in cancer, cAMP signaling pathway, cell cycle, glioma, neurotrophin cellular pathway, and calcium channel pathways were significantly linked with the mutational changes in TRIP-Brs in BRCA patients. Here, PIK3CA is linked to central nervous system cancer.