,22,25, 26, 27 Our and others’ ability to boost NIS expression in cancer cells by using HDACi has shown promises to circumvent the first issue mentioned above.18, 19, 20 Our data showing the effect of stable knockdown of HDAC1 results in mediating significant enhancement of NIS expression in MCF-7 cells further brings additional prospect to this approach. Here, HDAC1 is linked to cancer.