Non-benzamide classes of HDACi candidates like NaB and VPA show 3- to 7-fold increase of NIS promoter activity in both BC (ZR-75-1) and TC (ARO, NPA) lines, whereas CI-994, belonging to benzamide class HDACi, shows significant (p < 0.0001) gain of NIS promoter activity only in the ZR-75-1 cells (Figure 1A). The gene discussed is SLC5A5; the disease is breast cancer.