WAS and Thrombocytopenia: The exact functions of WASP in PLTs remains largely unknown, but there is strong evidence suggesting that it plays a critical role regulating MK differentiation and PLT formation by inhibiting these processes in the absence of the appropriated signals.18, 19, 20 This could sound contradictory with the thrombocytopenia found in WAS patients, but it is actually a potential explanation for it.