Among the 10 hub genes, all genes that showed association with the prognosis of HCC patients were found: CDC20 (P = 3.8e − 06), BUB1B (P = 0.0028), KIF11 (P = 0.00061), TTK (P = 0.0015), EZH2 (P = 5.6e − 05), ZWINT (P = 0.00061), NDC80 (P = 0.013), TPX2 (P = 0.00054), MELK (P = 0.0015), and KIF20A (P = 0.0034), respectively. The gene discussed is BUB1B; the disease is hepatocellular carcinoma.