Serum levels of MMP-2, MMP-8, and MMP-9 have been found increased in CKD patients and diabetic patients, being correlated, respectively, with serum phosphate (MMP-2), fibroblast growth factor-23 (FGF-23), and the degree of proteinuria (MMP-8 and MMP-9), two relevant predictors of oxidative stress and CV risk [61–63]. The gene discussed is MMP9; the disease is chronic kidney disease.