In the HF-150 group, plasma leptin concentration was higher [wk8: 4.5 (1.0–9.0) ng/ml vs. wk0: 2.0 (1.0–4.0) ng/ml; p = 0005], plasma adiponectin concentration was lower [wk8: 69.9 (15.8–283.5) ng/ml vs. wk0: 133.6 (40.7–287.0) ng/ml; p = 0.02] and plasma ghrelin concentration was similar [wk8: 0.49 (0.15–1.59) ng/ml vs. wk0: 0.56 (0.07–1.73) ng/ml; p = 0.08] at week 8 compared to week 0. Here, LEP is linked to hydrops fetalis.