CLDN2 and hydrops fetalis: In both groups at week 8, mRNA expressions of syndecan (HF-100 p = 0.04, HF-150 p = 0.001), claudin 2 (HF-100 p = 0.04, HF-150 p = 0.0002) and ZO1 (HF-100 p = 0.03, HF-150 p = 0.004) were significantly higher compared to week 0 (Figures 6B–D).