In recent years, a variety of studies have explored that collagen triple helix repeat containing-1 (CTHRC1) highly related to collagen synthesis was remarkably up-regulated in solid tumors (8–10), including hepatocellular carcinoma (11, 12), oral squamous cell carcinoma (13, 14), gastric carcinogenesis (9, 15), ductal carcinoma (16), and colorectal cancer (17–19), and that the expression abundance of CTHRC1 was significant low in normal tissues. Here, CTHRC1 is linked to hepatocellular carcinoma.