As we all know, there are four clinical triazoles agents targeting CYP51 for the treatment of systemic fungal infections: fluconazole (Flu), itraconazole (Itc), voriconazole (Vor), and posaconazole (Pos) (Lepesheva et al., 2018; Lee et al., 2020). The gene discussed is CYP51A1; the disease is fungal infectious disease.