Univariate and multivariate Cox analyses were performed in the training and validation cohorts based overall survival, using the available co-variables including risk score, age, gender, T classification, N classification, tumor stage, tumor location, race, KRAS status, EGFR status, STK11 status, or TP53 status to confirm whether the prognostic capacity of our eight-gene signature was independent from the clinico-pathologic characteristics. The gene discussed is TP53; the disease is neoplasm.