EGFR and glioblastoma: But recently, Felsberg et al. found EGFRvIII and EGFR SNVs are not prognostic; Chen et al. showed that there is insufficient evidence for the presence of either EGFR amplification or EGFRvIII mutation has prognostic value in patients with GBM using meta-analysis (Chen et al., 2015; Felsberg et al., 2017).