BRAF and glioblastoma: Ep-GBM, as a new variant of GBM, is more prevalent in children and young people, manifesting as superficial brain or mesencephalic masses, and often carries BRAF (Serine/threonine-protein kinase B-Raf) V600E mutations (Chapman et al., 2011; Kleinschmidtdemasters et al., 2013; Broniscer et al., 2014).