RCC1 and hepatocellular carcinoma: This has been demonstrated in several studies including Zhang et al. (2011), who found that 6-bromine-5-hydroxy-4-methoxybenzaldehyde was associated with the down-regulation of RCC1 protein expression during inducing mitotic catastrophe in human hepatocellular carcinoma (HCC) cells, and Qiao et al. (2018), where RCC1 knockdown inhibited G1/S cell cycle progression and DNA synthesis of HPV-E7 expressing cells.