CD274 and invasive breast carcinoma: More importantly, the depletion of DNA repair proteins, including Ku80 and breast invasive carcinoma (BRCA) 2, was found to enhance PD-L1 upregulation after DSBs, suggesting that patients with mutations of these proteins may highly express PD-L1 and thus benefit more from consolidative PD-1/PD-L1 blockade after RT or chemotherapy.