The function of Dvl C-terminal region in Wnt signaling is further demonstrated in autosomal-dominant Robinow syndrome caused by de novo frameshift mutations in human DVL1 and DVL3 genes, which delete and replace the C-terminal region after the DEP domain (Bunn et al., 2015; White et al., 2015, 2016; Danyel et al., 2018). This evidence concerns the gene DVL1 and autosomal dominant Robinow syndrome.