In the CI failed tendon healing animal model, chondrocyte phenotype and ossified region were observed (Lui et al., 2009), and the ectopic expression of BMP-2/4/7 was also observed around and in the chondrocyte-like cells and ossified region (Yee Lui et al., 2011), indicating the vital role of BMPs in the appearance of ectopic ossification, which was further corroborated by similar results observed in clinical specimens of tendinopathy (Rui et al., 2012b). The gene discussed is CLN5; the disease is disease of the tendon.