For example, Sdc-1 expression in inflammatory breast cancer is correlated with CD44, Notch-1, and Notch-3 expression, and siRNA knockdown of Sdc-1 results in a weaker CSC phenotype and reduced expression of Notch-1-4 and Hey1 in inflammatory breast cancer cells (Ibrahim et al., 2017). The gene discussed is NOTCH3; the disease is inflammatory breast carcinoma.