CASP1 and colorectal carcinoma: These findings in combination with results from IHC experiments demonstrating gC1qR-exon 6 being detectable in all paired normal colon tissues from analyzed CRC patient samples (Supplementary Figure 5F) point to a mere post-translational processing of gC1qR potentially by active caspase-1, leading to the loss of mitochondrial biogenesis and an increase of non-mitochondria localized gC1qR protein level (Figure 6G, Supplementary Figure 5G).