CASP1 and colorectal carcinoma: Based on our findings we demonstrated enhanced cell proliferation and a shift toward aerobic glycolysis after caspase-1 activation in gC1qR expressing cells (Figures 4, 5A–E) as well as decreased differentiation of colorectal carcinoma cells (Figures 5F–H), we hypothesized that grading and staging of colorectal carcinoma cells may be correlated with caspase-1 mediated cleavage of gC1qR.