Notably, significant up-regulation of C1qbp and the cell proliferation marker Ki67 mRNA expression level were determined in tumor tissues compared to paired normal tissues (Figures 6B,C), while no correlation was found in colonic tissues between C1qbp and Ki67 mRNA level, between NLRP3 and Ki67 mRNA level as well as between PYCARD and Ki67 mRNA level (Supplementary Figures 5B–D). Here, NLRP3 is linked to neoplasm.