Here, in contrast to healthy colonic tissue (Figure 1G, Supplementary Figure 1) protein expression of gC1qR negatively correlated with the mitochondrial marker TOM22 and was highest in grade 4 (G4) and lowest in grade 1 (G1) CRC (Figure 6G), although C1qbp mRNA expression did not correlate with tumor stage and grade (Figures 6E,F). This evidence concerns the gene TOMM22 and colorectal carcinoma.