We also reported that ABTB2 is related to the resistance of breast cancer cells to epirubicin and the prognosis of ER-positive breast cancer, suggesting that SNP rs6484711 variant A allele can be used as a predictive marker for the efficacy of epirubicin combined with docetaxel for NAC in luminal A breast cancer and ABTB2 can be used as a prognostic marker for ER-positive breast cancer. The gene discussed is ABTB2; the disease is breast cancer.