TP53 and hepatocellular carcinoma: In terms of tumor suppressors, tumor protein 53 (TP53) has been consistently reported as one of the most important genes mutated in cHCC-ICC; the largest comparative genomics study to date has shown that TP53 mutations were more frequent in cHCC-ICC compared to HCC and ICC alone [49.2 vs. 31% (p < 0.001) and 22% (p < 0.0001), respectively] (19, 47).