cHCC-ICC studies integrating both genomics and transcriptomics using RNA-seq, WES and whole genome sequencing (WGS) find similar patterns in changes of key genes and tend to find more similarities between cHCC-ICC [especially Lisa and Allen type C (poorly defined transition) cHCC-ICC] and HCC, such as in TP53 and CTNNB1, rather than ICC (even ICCs arising in cirrhotic livers). The gene discussed is TP53; the disease is intrahepatic cholangiocarcinoma.