FOXM1 and metastatic malignant neoplasm in the lymph nodes: Patients with low expression levels of miR-149 are more likely to present with a poor prognosis, such as lymph node metastasis, distant metastasis, or more malignant TNM grades, and miR-149 could bind to mRNA of FOXM1 and then suppress its expression, thereby inhibiting the proliferation, metastasis, and invasiveness of colorectal cancer cells, which suggests that miR-149 could play a role as a tumor suppressor gene in colorectal cancer (30).