Analysis of the TCGA-KIRC database suggested that elevation of METTL3, IGF2BP1, IGF2BP2, and IGF2BP3 and decreased expressions of ALKBH5, FTO, METTL14, YTHDF2, YTHDC1, YTHDC2, ZC3H13, METTL16, KIAA1429, CBLL1, and RBM15 in ccRCC were associated with poor OS probability. The gene discussed is YTHDC2; the disease is nonpapillary renal cell carcinoma.