Furthermore, multivariate Cox regression model revealed that YTHDF2 (HR = 0.471, 95% CI: 0.241–0.920; P = 0.028) as well as age (HR = 2.118, 95% CI: 1.142–3.931; P = 0.017) and cancer status (HR = 3.329, 95% CI: 1.608–6.526; P = 0.001) served as independent prognostic factors (P < 0.05). This evidence concerns the gene YTHDF2 and cancer.