These weaknesses can be addressed by serological RDTs, which detect the more stable viral immunogenic proteins such as the S and N proteins, which persist more than RNA or anti-SARS-CoV-2 IgM and IgG which have been reported to peak between 2 and 3 weeks and 17 days post infection onset.26,27 Guo et al.28 reported an improvement of COVID-19 identification by RT-PCR from 51.9% to 98.6% with the integration of an IgM-based immunoassay. Here, CD40LG is linked to COVID-19.