Obesity leads to the development of multiple metabolic disorders.[22, 23] In contrast, weight loss, achieved by using bypass surgery or other associated procedures, have been proven to confer effective therapeutic benefit.[24] From our data, deficiency of FBXW2 in macrophage is shown to be a major origin of anti‐inflammatory and anti‐obesity signal curbing the progression of metabolic diseases. Here, FBXW2 is linked to Other metabolic disease.