Because FBXW2 (P3) acted as an inhibitor of KSRP ubiquitination and exhibited potent protective effects against LPS‐induced inflammation in vitro, we next investigated the therapeutic effects of this segment in murine models of HFD/WD‐induced obesity and atherosclerosis. The gene discussed is KHSRP; the disease is obesity due to melanocortin 4 receptor deficiency.