We further discovered that FBXW2 (P3), the C‐terminal WD40 repeat domains of FBXW2, blocks the SCFFbxw2‐KSRP association and KSRP degradation, thus in turn, retarding the progress of obesity and atherosclerosis. The gene discussed is FBXW2; the disease is obesity due to melanocortin 4 receptor deficiency.