Ubiquitination has emerged as a crucial protein posttranslational modification within the cells, as it plays a critical role in maintaining multiple cellular functions.[27] FBXW2, a substrate recognition component of the Skp1‐Cullin‐F‐box (SCF)‐type E3 ligase complex, balances physiological and pathological dysfunction in initiation and progression of tumor by mediating the ubiquitination and degradation of various targets, such as Skp2, GCM1, β‐Catenin, and MSX2.[12, 21, 27, 28] However, our data revealed that KSRP is a new target of FBXW2. Here, CACUL1 is linked to neoplasm.