In addition, CSN6, COP1, FOXO4, PHGDH, PSAT1, and SHMT2 demonstrated a significant correlation in staining intensity in five pairs of primary tumor/normal tissue samples as expected (Figure 8C), i.e., high CSN6 expressing tumors have lower levels of FOXO4 with concurrent high expression of COP1, PHGDH, PSAT1, and SHMT2. This evidence concerns the gene SHMT2 and neoplasm.