It could suppress tumor development through inhibiting cancer cell proliferation (targeting p27, p21), promoting cancer cells apoptosis (targeting Bcl6, caspase3), and hindering cancer cells metastasis (targeting E‐cadherin) and tumor angiogenesis (targeting HIF‐1α).[12] Its mechanistic role as a tumor suppressor is very important, but the upstream regulators/downstream targets of FOXO4 and its post‐transcriptional modification in tumorigenesis remain not well characterized. This evidence concerns the gene HIF1A and neoplasm.