BRCA2 and familial pancreatic carcinoma: In addition, about 10% of PDAC manifestations are inherited, and the best-studied germline mutations linked to familial pancreatic cancer risk are the components of DNA double-strand break repair machinery, including BRCA1, BRCA2, PALB2 (partner and localizer of BRCA2), the Fanconi anemia genes FANCC and FANCG, and ATM (ataxia telangiectasia mutated) [23].