Both OXY-KLH and OXY-sKLH are effective in preventing oxycodone-distribution to the brain, and reducing oxycodone-induced antinociception, motor activity, respiratory depression and bradycardia, as well as acquisition of oxycodone intravenous self-administration15–17,34,57. The gene discussed is GCG; the disease is Respiratory insufficiency due to muscle weakness.