FuSiOn identified ten kinases (BMP2K, DCLK3, LIMK2, MAP2K5/MEK5, MAP3K3/MEKK3, ROS1, SIK2, TAOK2, ULK1, and ULK2) whose depletion mimicked the phenotypic effect of p62 depletion in HCT116 colon cancer cells46. This evidence concerns the gene MAP2K5 and colonic neoplasm.