FuSiOn identified ten kinases (BMP2K, DCLK3, LIMK2, MAP2K5/MEK5, MAP3K3/MEKK3, ROS1, SIK2, TAOK2, ULK1, and ULK2) whose depletion mimicked the phenotypic effect of p62 depletion in HCT116 colon cancer cells46. Here, SIK2 is linked to colonic neoplasm.