Additionally, a recent investigation described a whole set of different pathways and additional enzymatic reactions involved in the compensatory response of pancreatic cancer against CB839 [61] including branched chain aminotransferase 1 (BCAT1), gamma-glutamyl hydrolase (GGH), and 5-oxoprolinase (OPLAH). This evidence concerns the gene BCAT1 and familial pancreatic carcinoma.