The results of Western blotting showed that the levels of iNOS, COX2, p-p65, and Cleaved-caspase-1 were increased in MPTP-induced PD mice, while pretreatment with crocetin to MPTP-treated mice distinctly decreased the expression of iNOS, COX2, p-p65, and Cleaved-caspase-1 (Figure 2(a)). Here, CASP1 is linked to Parkinson disease.