In this study, we found that pretreatment with crocetin distinctly decreased the expression of inflammatory associated genes (p-p65 and Pro-/Cleaved-caspase-1) and inflammatory cytokines (IL-1β, IL-6, IL-10, TNF-α, iNOS, and COX-2) in MPTP-induced PD mice and BV2 cells stimulated with MPP+. Here, CASP1 is linked to Parkinson disease.