For example, programmed death-1 (PD-1) and programmed death-ligand-1 (PD-L1) inhibitors have been found to induce tumor cell apoptosis by blocking the PD-1/PD-L1 signaling pathway, thus playing an effective antitumor role in lung cancer and melanoma [13, 19–21]. The gene discussed is CD274; the disease is melanoma.