SNCA and Parkinson disease: Resveratrol is a very promising polyphenol, showing inhibition of α-synuclein aggregation in PD-induced mice [226], increased lifespan of MPTP-treated D. melanogaster [227], and protection for PC12 cells from rotenone oxidative damage, an effect partially mediated through the activation of the SIR/Akt1 signaling pathway [228].