A novel Nrf2-ARE activator, DDO-7263 was tested against MPTP-induced PD in mice, improving behavioral abnormalities induced by MPTP and significantly attenuating chemically induced dopaminergic neuron loss of tyrosine hydroxylase in the substantia nigra and striatum. In addition, DDO-7263 inhibited the secretion of inflammatory factors and protected PC12 neurons from H2O2-induced oxidative damage [276]. This evidence concerns the gene NFE2L2 and Parkinson disease.