Moreover, the prooxidant effect of MPTP in animal models of PD was minimized using paroxetine (an antidepressant drug), which promoted the reduction of astroglial MPO expression, production of ROS through NADPH oxidase, and the expression of proinflammatory cytokines, decreasing the loss of dopaminergic neurons and improving motor functions. The gene discussed is MPO; the disease is Parkinson disease.