A total of thirteen CSC-associated genes were selected in this study, and all of the genes included in the CSC gene-based signature have been experimentally confirmed to be linked with cancer and of them including CTNNBIP1, FDZ5, LATS2, NAMPT, GREM1, PRKACB, and WNT4 have been proved to have an oncogenic or prognostic role in PCa. The gene discussed is PRKACB; the disease is cancer.