Similarly, the ROC plot yielded AUC of 0.81 and 0.88 between HBLC vs HCs and HCC vs HCs, respectively, indicating that the serum CMTM2 had a high value for identifying patients with HBLC and HCC from HCs, while it had no diagnostic value for identifying HBLC and HCC from CHB. Here, CMTM2 is linked to hepatocellular carcinoma.