IL10 and chronic kidney disease: It has been shown that EVs derived from MSCs can improve the overall kidney function of CKD patients by increasing the IL-10 levels and repairing the glomerular filtration rate [33]; however, in this study, hypertensive animals showed no alterations in serum creatinine, suggesting a compensatory mechanism of the contralateral kidney and corroborating previously published studies [10, 11, 34].