SHBG and metabolic syndrome: Table 3 shows that SHBG is associated with MetS (OR: 0.96; 95% confidence interval: 0.95–0.97, P < 0.001). The ROC curve of SHBG for MetS is demonstrated in Figure 1. The area under the curve was 0.732 with a 95% confidence interval of 0.695–0.770. The SHBG cutoff point of <26.75 mmol/L had the highest Youden index, with a sensitivity of 0.656 and a specificity of 0.698 (Table 4).