FGF2 and Parkinson disease: We found that FGF2-triggered EVs were specifically enriched for Rab8b and Rab31. Hence, to further conclude on the global effects of Rab8b and Rab31 enrichment and their importance in PD pathology, we performed protein–protein interaction network (PPiN) analysis and identified their interactions in different CNS-resident cell types, in different brain regions, and in ENS, highlighting the novel role of FGF2 in PD pathophysiology and paving a way forward to investigating the specific role of FGF2 in PD.