Consistent with our results in train cohort, the average expression levels of FOXM1, NEK2, CCT2, ACTL6A, EIF4A3, CCND2, ABL1, SYNCRIP, ITGB1, ENAH, and UMPS in CNS and brain tumor tissues were significantly higher than those in normal tissues. The gene discussed is ITGB1; the disease is brain neoplasm.