PLAGL1 and Beckwith-Wiedemann syndrome: The most frequently altered iDMRs found in BWS patients with MLID are PLAGL1, GRB10, MEST, GNAS, IGF2R, and ZNF331. From a pathological point of view, usually, MLID BWS patients have a decreased level of body weight compared to the one who characterized by a single molecular defect in the 11p15.5 region.