In a cohort study, MLID was identified only in BWS patients with KCNQ1OT1:TSS-DMR LOM and hypomethylation was found only at maternally iDMRs, a condition described as multiple maternal hypomethylation syndrome (MMHS) (Bliek et al., 2009b; Sano et al., 2016; Fontana et al., 2018). The gene discussed is KCNQ1OT1; the disease is Beckwith-Wiedemann syndrome.