The four main molecular subtypes of BWS (KCNQ1OT1:TSS-DMR-LOM, H19/IGF2:IG-DMR -GOM, UPD, and CDKN1C mutations) are characterized by specific genotype-phenotype correlation to tumor development risk (Ibrahim et al., 2014; Mussa et al., 2016a). Here, IGF2 is linked to neoplasm.