Patients with H19/IGF2:IG-DMR hypermethylated present Wilms tumor and hepatoblastoma their recurrence is related to IGF2 overexpression during cancer development (Akmal et al., 1995; Rump et al., 2005; Maas et al., 2016; Mussa et al., 2017; Brioude et al., 2019). The gene discussed is IGF2; the disease is cancer.